Study: van Es, 2009

Population Ethnicity Diagnosis Source # Cases (% women) # Controls (% women) AAO (sd) AAO range AAE (sd) AAE range Ctrl age (sd) Ctrl age range # Polymorphisms
UK (REP) C Escorial 1 CL 212 237 - - - - - - 60

Polymorphisms in this population [-]

Polymorphism Location (hg19) Gene Allele contrast Ethnicity # Studies # Samples 1000G CEU 1000G CHB+JPT Meta OR (95%CI) I2 (95%CI) Meta P-value
rs2045333 chr1:2801459 intergenic - - - - 0.108 (T) 0.008 (T) - - -
rs17429690 chr1:5814135 intergenic A vs. G All: C 8 14,948 0.083 (A) - 1.09 (0.98-1.20) 0 (0-57) 0.111
rs6700125 chr1:59702797 intergenic T vs. C All: A, C 10 17,691 0.217 (T) 0.492 (T) 1.05 (0.99-1.12) 0 (0-19) 0.110
rs10489650 chr1:79730753 intergenic C vs. T All: C 8 14,948 0.3 (C) 0.475 (C) 1.08 (1.01-1.16) 44 (0-75) 0.031
rs11264236 chr1:153658480 NPR1 - - - - 0.242 (A) 0.167 (A) - - -
rs1776148 chr1:242042545 EXO1 A vs. G All: C 8 14,948 0.275 (A) 0.217 (A) 1.16 (1.08-1.24) 0 (0-38) 2.69e-05
rs1706871 chr2:2472155 intergenic G vs. A All: C 8 14,948 0.483 (G) 0.35 (A) 0.90 (0.85-0.96) 38 (0-72) 0.002
rs823538 chr2:2493770 intergenic A vs. G All: C 8 14,948 0.467 (A) 0.325 (A) 1.12 (1.04-1.19) 13 (0-55) 0.001
rs7565870 chr2:52030757 CRYGGP [+28217bp] T vs. C All: C 8 14,948 0.167 (T) 0.033 (T) 0.90 (0.84-0.97) 0 (0-42) 0.007
rs350729 chr2:52983773 intergenic - - - - 0.275 (T) 0.442 (G) - - -
rs6729829 chr2:81487685 intergenic - - - - 0.233 (A) 0.292 (A) - - -
rs1396919 chr2:115827788 DPP10 G vs. A All: C 8 14,948 0.2 (G) 0.208 (G) 1.08 (0.99-1.18) 15 (0-58) 0.077
rs6759238 chr2:218536449 DIRC3 G vs. A All: C 8 14,948 0.425 (G) 0.467 (A) 0.94 (0.88-1.01) 55 (1-80) 0.086
rs6431612 chr2:239511024 intergenic T vs. C All: C 8 14,948 0.283 (T) 0.0 (T) 0.97 (0.91-1.04) 60 (13-82) 0.405
rs10460926 chr3:82488068 intergenic - - - - 0.133 (T) 0.417 (T) - - -
rs938111 chr3:116847881 LSAMP G vs. T All: C 8 14,948 0.133 (G) 0.483 (T) 1.11 (1.00-1.22) 21 (0-63) 0.045
rs4266132 chr3:137210535 RNA5SP142 [-26441bp] G vs. A All: C 8 14,948 0.2 (G) 0.142 (G) 1.07 (0.99-1.16) 0 (0-64) 0.107
rs2723708 chr4:169592669 PALLD - - - - 0.417 (G) 0.358 (G) - - -
rs917379 chr5:129457924 CHSY3 - - - - 0.125 (T) 0.3 (T) - - -
rs10079678 chr5:129506648 CHSY3 - - - - 0.1 (C) 0.0 (C) - - -
rs9327807 chr5:137350478 FAM13B C vs. T All: C 8 14,948 0.142 (C) - 0.87 (0.79-0.95) 0 (0-65) 0.001
rs3734399 chr6:11138038 SMIM13 - - - - 0.133 (G) 0.383 (G) - - -
rs9393338 chr6:22827583 intergenic A vs. C All: C 8 14,948 0.05 (A) 0.425 (C) 0.79 (0.70-0.90) 0 (-) 3.64e-04
rs3799386 chr6:136450147 PDE7B T vs. C All: C 8 14,948 0.333 (T) 0.317 (T) 1.06 (0.99-1.13) 64 (24-83) 0.092
rs3757155 chr6:136458593 PDE7B - - - - 0.35 (T) 0.35 (T) - - -
rs2046091 chr6:136459249 PDE7B G vs. A All: C 8 14,948 0.375 (G) 0.425 (G) 1.05 (0.98-1.12) 68 (32-85) 0.201
rs10260404 chr7:154210798 DPP6 - - - - 0.467 (C) 0.167 (C) - - -
rs17643851 chr8:18437729 PSD3 - - - - 0.033 (G) 0.125 (G) - - -
rs2814707 chr9:27536397 MOB3B [+6618bp] C vs. T All: A, C 9 11,047 0.217 (T) 0.042 (T) 0.84 (0.77-0.90) 48 (0-76) 5.47e-06
rs3849942 chr9:27543281 C9orf72 [-3263bp] T vs. C All: C 14 20,662 0.217 (T) 0.058 (T) 1.20 (1.14-1.26) 73 (54-84) 3.61e-12
rs774359 chr9:27561049 C9orf72 C vs. T All: C 9 15,850 0.25 (C) 0.067 (C) 1.25 (1.16-1.34) 72 (46-86) 4.31e-10
rs450652 chr9:89824013 C9orf170 [+49542bp] A vs. G All: C 8 14,948 0.067 (A) - 0.83 (0.73-0.94) 17 (0-60) 0.003
rs395119 chr9:131996071 intergenic C vs. T All: C 8 14,948 0.275 (C) 0.458 (C) 1.11 (1.04-1.20) 0 (0-64) 0.004
rs201074 chr10:10997313 CELF2 [-49946bp] A vs. G All: C 8 14,948 0.467 (A) 0.075 (A) 0.92 (0.86-0.98) 0 (0-66) 0.009
rs11595807 chr10:21768926 CASC10 [-12661bp] G vs. T All: C 8 14,948 0.058 (G) - 1.09 (0.97-1.22) 80 (61-90) 0.132
rs11007742 chr10:30076326 intergenic A vs. G All: C 8 14,948 0.083 (A) 0.175 (A) 1.11 (1.00-1.23) 0 (0-42) 0.053
rs3817287 chr10:124096387 BTBD16 G vs. A All: C 8 14,948 0.3 (G) 0.325 (A) 1.05 (0.98-1.13) 33 (0-70) 0.173
rs2014307 chr10:124217632 ARMS2 [+764bp] T vs. G All: C 8 14,948 0.342 (T) 0.358 (T) 1.09 (1.02-1.17) 38 (0-73) 0.007
rs4944178 chr11:77593221 AAMDC - - - - 0.125 (T) 0.225 (T) - - -
rs2405657 chr11:97682564 intergenic A vs. G All: C 10 14,808 0.3 (A) 0.425 (G) 0.86 (0.81-0.92) 16 (0-57) 1.25e-05
rs9971637 chr12:17373739 intergenic - - - - 0.058 (A) 0.067 (A) - - -
rs7956931 chr12:18382387 RERGL G vs. T All: C 8 14,948 0.133 (G) 0.283 (T) 0.94 (0.86-1.02) 51 (0-78) 0.150
rs2306677 chr12:26636386 ITPR2 A vs. G All: A, C 5 3,576 0.092 (A) 0.217 (A) 0.90 (0.78-1.03) 0 (0-51) 0.118
rs310819 chr12:77492074 E2F7 [+32714bp] A vs. G All: C 8 14,948 0.317 (A) 0.417 (G) 1.12 (1.04-1.19) 19 (0-62) 0.002
rs1527047 chr12:77773549 intergenic A vs. G All: C 8 14,948 0.383 (A) 0.417 (G) 0.89 (0.83-0.95) 0 (0-67) 7.61e-04
rs11159460 chr14:80872935 DIO2 [+18835bp] C vs. A All: C 8 14,948 0.342 (C) 0.367 (C) 0.91 (0.85-0.98) 51 (0-78) 0.008
rs7161223 chr14:96127082 TCL1B [-25672bp] G vs. A All: C 8 14,948 0.292 (G) 0.383 (A) 0.93 (0.87-0.99) 22 (0-64) 0.033
rs613479 chr15:34359190 CHRM5 [+1899bp] T vs. C All: C 8 14,948 0.4 (T) 0.442 (C) 0.94 (0.88-1.01) 39 (0-73) 0.077
rs1989 chr15:83781631 TM6SF1 - - - - 0.1 (T) 0.008 (T) - - -
rs12162045 chr16:23331743 SCNN1B A vs. G All: C 8 14,948 0.308 (A) 0.217 (A) 1.07 (0.99-1.15) 0 (0-58) 0.088